Effect of Cephalexin on Virulent <I>Treponema pallidum</I>

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  • Cephalexinの病原性<I>Treponema pallidum</I>にたいする効果
  • Cephalexinの病原性Treponema pallidumにたいする効果
  • Cephalexin ノ ビョウゲンセイ Treponema pallidum ニ タイスル コウカ
  • Effect of Cephalexin on Virulent Treponema pallidum

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Abstract

Effect of cephalexin (CEX) on virulent Treponema pallidum Nichols strain was investigated. The results were summarized as follows:<BR> 1) The VDRL titer of 7 rabbits were determined following intratesticular infection with T. pallidum and after oral administration of CEX 80mg per kg per day for 2, 5 or 10 days. Those animal treated with CEX for 5 days or 10 days exhibited rapid decrease of VDRL titer, but for 2 days only a few decrease.<BR> 2) Syphilitic orchitis which occurred following infection disappeared after 10 days from the beginning of the treatment with CEX. T. pallidum from the lesion were immobilized after 2 days treatment.<BR> 3) To investigate the direct effect of CEX on T. pallidum in vitro T. pallidum from the syphilitic orchitis were incubtead in medium containing various amount of CEX for 17 hours. It was found that 100% T. pallidum were immobilized by the CEX concentration at 0.002 μg/ml, 70% of T. pallidum were immobilized at 0.001 μg/ml CEX.<BR> 4) Five patients with ulcus durum, ulcus mixtum, congenital syphilis or syphilis latens were treated with CEX. Healing of the lesions and the decrease of antibody titer were observed in all patients.

Journal

  • Nishi Nihon Hifuka

    Nishi Nihon Hifuka 35 (6), 722-730, 1973

    Western Division of Japanese Dermatological Association

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