A Case of Fibrotic Change of Muscles Secondary to Lupus Erythematosus Profundus

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  • TAKANO Yukako
    Department of Anatomy, Biology and Medicine (Dermatology), Faculty of Medicine, Oita University
  • TUBONE Takao
    Department of Anatomy, Biology and Medicine (Dermatology), Faculty of Medicine, Oita University
  • GOTO Mizuki
    Department of Anatomy, Biology and Medicine (Dermatology), Faculty of Medicine, Oita University
  • KATO Aiko
    Department of Anatomy, Biology and Medicine (Dermatology), Faculty of Medicine, Oita University
  • KATAGIRI Kazumoto
    Department of Anatomy, Biology and Medicine (Dermatology), Faculty of Medicine, Oita University
  • FUJIWARA Sakuhei
    Department of Anatomy, Biology and Medicine (Dermatology), Faculty of Medicine, Oita University
  • YOKOYAMA Shigeo
    Department of Oncological Science (Pathology), Faculty of Medicine, Oita University
  • HAZAMA Yusuke
    Department of Neurology and Neuromuscular Disorders, Faculty of Medicine, Oita University
  • KUMAMOTO Toshihide
    Department of Neurology and Neuromuscular Disorders, Faculty of Medicine, Oita University

Bibliographic Information

Other Title
  • Ｌｕｐｕｓ　Ｅｒｙｔｈｅｍａｔｏｓｕｓ　Ｐｒｏｆｕｎｄｕｓに伴って筋の線維化を認めた１例
  • 症例 Lupus Erythematosus Profundusに伴って筋の線維化を認めた1例
  • ショウレイ Lupus Erythematosus Profundus ニ トモナッテ スジ ノ センイカ オ ミトメタ 1レイ

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Abstract

A 56-year-old man with bilateral erythema on his cheeks, presented at our hospital in 1996. He was diagnosed as having discoid lupus erythematosus. Since then, he has not presented with the complaint. In 2005, subcutaneous nodules appeared on his right cheek and left thigh. Because the thigh lesions gradually become painful, he consulted a nearby orthopedist. MRI results suggested localized myositis of his left thigh that might be related to the subcutaneous nodule, and he was referred to our hospital. We diagnosed both the lesions of his right cheek and his left thigh as lupus erythematosus profundus, based on biopsy and MRI findings. The biopsy from his left gracilis muscle showed that the muscle and the fascia were gray in color, and revealed myositis and fibrotic changes of the muscle. Although the levels of creatinine kinase, aldolase, and myoglobin were high intermittently, muscle weakness of the bilateral upper limbs and right lower leg, dysphagia, and other general symptoms were not found. In 2007, tests for anti-Sm antibody and anti-U1-RNP antibody became positive. However, systemic involvement of the lung or kidney were not detected. The deep inflammatory changes of lupus erythematosus profundus reached to the underlying muscle, which resulted in the fibrotic changes.

Journal

  • Nishi Nihon Hifuka

    Nishi Nihon Hifuka 71 (1), 11-16, 2009

    Western Division of Japanese Dermatological Association

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