A Case of Epithelioid Sarcoma.

DOI 2 Citations 12 References
  • TASHIRO Kenji
    Department of Dermatology, Faculty of Medicine, Kyushu University
  • TAKEUCHI Minoru
    Department of Dermatology, Faculty of Medicine, Kyushu University First Department of Pathology, Faculty of Medicine, Kyushu University
  • IMAYAMA Shuhei
    Department of Dermatology, Faculty of Medicine, Kyushu University
  • NAGAE Shonosuke
    Department of Dermatology, Faculty of Medicine, Kyushu University
  • HORI Yoshiaki
    Department of Dermatology, Faculty of Medicine, Kyushu University

Bibliographic Information

Other Title
  • 類上皮肉腫

Search this article

Description

We report a case of epithelioid sarcoma with its immunohistochemical and ultrastructural findings. A 36-year-old female noticed a nodule on her right thumb 6 years before her first visit our clinic. A histological examination revealed only a granulomatous proliferation of slightly atypical ovoid to spindle-shaped cells in the dermis along with thickened collagen bundles. Two and a half years later the patient presented with secondary nodules which developed on both the right upper extremities and the axillary region together with the ulceration of the primary skin lesion. A histological examination revealed a compact proliferation of ovoid to polygonal shaped cells with highly atypical nuclei and abundant eosinophilic cytoplasm in the dermis to subcutis. Among these cells, there were some scattered clefts with erythrocytes which mimicked angiosarcoma. Immunohistochemically, the proliferating cells were positive for vimentin and low molecular weight cytokeratin, but were negative for factor VIII related antigen, Ulex Europaeus aggulutinin, S-100 protein, lysozyme, and alpha-1 antitrypsin. Electron microscopic studies demonstrated that the proliferating cells were characterized by abundant intermediate filaments, numerous microvilli, and basal lamina surrounding the tumor cells, suggesting a close relation to synovial sarcoma.

Journal

Citations (2)*help

See more

References(12)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top