Two Cases of Plasmocytosis Circumorificialis

  • KONDOH Akio
    Division of Specialized Clinical Science (Dermatology), Tokai University School of Medicine
  • UMEZAWA Yoshinori
    Division of Specialized Clinical Science (Dermatology), Tokai University School of Medicine
  • OHTA Yukinori
    Division of Specialized Clinical Science (Dermatology), Tokai University School of Medicine
  • IIZUKA Mariko
    Division of Specialized Clinical Science (Dermatology), Tokai University School of Medicine
  • MATSUYAMA Takashi
    Division of Specialized Clinical Science (Dermatology), Tokai University School of Medicine
  • OZAWA Akira
    Division of Specialized Clinical Science (Dermatology), Tokai University School of Medicine
  • YAMAMOTO Osamu
    Yamamoto Hihuka

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Other Title
  • 開口部形質細胞症の2例

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Case 1 : A 69-year-old male presented with erosion in the right lower lip that appeared 10 years ago. The lesion showed erythema of 1.5×0.8 cm in diameter and erosion of 5 mm in diameter, respectively. Case 2 : A 59-year-old male presented with erosion in the left lower lip that appeared about 4 months ago. That lesion showed erythema of 1.2×0.7 cm in size and a shallow ulcer about 5 mm in diameter in the center. Histopathologically, both cases were diagnosed as plasmocytosis circumorificialis with a dense infiltration of plasmacytes found in the corium. Case 1 was almost cured with topical injection of triamcinolone acetonide. Case 2 was almost cured with topical administration of 0.1% triamcinolone acetonide. The treatment of plasmocytosis circumorificialis was studied in 73 cases reported in Japan. Topical administration of steroid preparations is given most frequently but its efficacy rate was low at about 40%. On the other hand, the efficacy rate of local steroid injection therapy, oral administration of griseofulvin and total resection was high at 82.3%, 50.0% and 85.7% respectively, although the number of cases reported was small. When the lesion is incurable with topical steroid therapy, other therapies should be tried.

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