Study on Clinical Effects of Topical Corticosteroid Clobetasol 17-Propionate

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Other Title
  • 外用コルチコステロイド 0.05% Clobetasol 17-Propionateの臨床効果についての検討
  • ガイヨウ コルチコステロイド 0 05パーセント Clobetasol 17

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Clinical effects of 0.05% clobetasol 17-propionate cream (SN-201·C) and 0.05% clobetasol 17-propionate ointment (SN-201·O) were studied by simple application (SA) method in principle, by a study group consisting of 27 institutes, with the patients of dermatological diseases: acute eczematous dermatitis, seborrheic eczema, chronic eczematous dermatitis, atopic dermatitis, dermatitis on hand, prurigo, pustulosis palmaris et plantaris and psoriasis vulgaris. The following results were obtained.<BR> 1) The 684 cases were treated with SN-201·O and SN-201·O…321 cases with SN-201·C and 363 cases with SN-201·O. The effective ratio was: 302/321=94.1% with SN-201·C and 336/363=92.6% with SN-201·O.<BR> 2) When compared with betamethasone 17-valerate and fluocinolone acetonide, SN-201 proved to be significantly more effective.<BR> 3) Side effects were observed in 46 cases with SN-201: irritating sensation in nine cases, folliculitis in nine, exanthema acneiform in six, xeroderma in ten, drying sensation in seven, telangiectasia in one, chaps in three and hypertrichosis in one case, but any of them were not so serious.

Journal

  • Nishi Nihon Hifuka

    Nishi Nihon Hifuka 37 (4), 622-632, 1975

    Western Division of Japanese Dermatological Association

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