Drug Eruption Induced by Imatinib Mesylate (Glivec)

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  • INOUE Yuji
    Department of Dermatology, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University
  • IHN Hironobu
    Department of Dermatology, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University
  • GYOTOKU Takashi
    Gyotoku Dermatologic Clinic
  • IKEDA Isamu
    Division of Dermatology, Omuta Tenryo Hospital

Bibliographic Information

Other Title
  • メシル酸イマチニブ（グリベック）による薬疹
  • 症例 メシル酸イマチニブ(グリベック)による薬疹
  • ショウレイ メシルサン イマチニブ グリベック ニ ヨル ヤクシン

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Description

We report a 58-year-old woman with drug eruptions induced by the BCR-ABL tyrosine kinase inhibitor, Glivec®. One month after the beginning of administration of Glivec® (400 mg/day), multiple areas of erythema over the entire body with itching erupted. We obtained a biopsy specimen of the erythema and made the diagnosis of erythema exudative multiforme. We treated the patient with corticosteroid administration (betamethasone 0.5 mg/day) and reduced the dosage of Glivec® (200 mg/day). One month later, the erythema reappeared and hyperkeratosis with scales on the palms and soles appeared. Purpura on both legs followed in two months. DLST for Glivec® was negative. We also reported 4 other cases with drug eruptions induced by Glivec®.

Journal

  • Nishi Nihon Hifuka

    Nishi Nihon Hifuka 69 (5), 501-504, 2007

    Western Division of Japanese Dermatological Association

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