Fulminant Type 1 Diabetes Mellitus Associated with Drug Induced Hypersensitivity Syndrome by Zonisamide (Excegran)

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  • KAJIHARA Ikko
    Division of Dermatology, Kumamoto Municipal Hospital
  • ICHIHARA Asako
    Division of Dermatology, Kumamoto Municipal Hospital
  • HIGO Jyunko
    Division of Dermatology, Kumamoto Municipal Hospital
  • KIDOU Masato
    Division of Dermatology, Kumamoto Municipal Hospital
  • TODAKA Mikio
    Division of Metabolic Medicine, Kumamoto Municipal Hospital
  • IHN Hironobu
    Department of Dermatology & Plastic and Reconstructive Surgery, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University

Bibliographic Information

Other Title
  • 劇症１型糖尿病を合併したゾニサミド（エクセグラン）によるＤｒｕｇ‐ｉｎｄｕｃｅｄ　Ｈｙｐｅｒｓｅｎｓｉｔｉｖｉｔｙ　Ｓｙｎｄｒｏｍｅ　（ＤＩＨＳ）の１例
  • 症例 劇症1型糖尿病を合併したゾニサミド(エクセグラン)によるDrug-induced Hypersensitivity Syndrome(DIHS)の1例
  • ショウレイ ゲキショウ 1ガタ トウニョウビョウ オ ガッペイシタ ゾニサミド エクセグラン ニ ヨル Drug induced Hypersensitivity Syndrome DIHS ノ 1レイ

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Abstract

We reported a 61-year-old man who developed fulminant type 1 diabetes mellitus associated with drug-induced hypersensitivity syndrome (DIHS). Four weeks after the beginning of administration of Zonisamide (Excegran®) for convulsion from cerebral hemorrhage, he presented with papuloerythematous lesions over the entire body, high fever and swelling of the lymph nodes. Laboratory examination revealed atypical lymphocytes, and increased levels of transaminase and a high anti-human herpes virus 6 IgG titer. DLST of Excegran® was positive. He was diagnosed as having DIHS due to Excegran®. Eleven days after the onset of the eruptions, he developed fulminant type 1 diabetes mellitus. Furthermore, he had CMV enteritis/pneumonia, bacterial pneumonia and liver cirrhosis. He died of septic shock 69 days after the eruption onset.

Journal

  • Nishi Nihon Hifuka

    Nishi Nihon Hifuka 70 (5), 482-486, 2008

    Western Division of Japanese Dermatological Association

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