Studies on Adrenocortical Suppression Following Percutaneous Absorption of Topical Corticosteroids
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- ASO Miki
- Department of Dermatology, Tottori University School of Medicine
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- TAKEHAR Naohide
- Department of Dermatology, Tottori University School of Medicine
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- KANBE Naoto
- Department of Dermatology, Tottori University School of Medicine
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- INOUE Taeko
- Department of Dermatology, Tottori University School of Medicine
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- SHIMIZU Yasuyuki
- Department of Dermatology, Tottori University School of Medicine
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- MIHARA Motoyuki
- Department of Dermatology, Tottori University School of Medicine
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- SHIMAO Shuhei
- Department of Dermatology, Tottori University School of Medicine
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- USUI Toshiaki
- Division of Chemistry, Institute of Steroid Research Tottori University School of Medicine
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- KAWAMOTO Hiroko
- Division of Chemistry, Institute of Steroid Research Tottori University School of Medicine
Bibliographic Information
- Other Title
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- 外用コルチコステロイド経皮吸収による副腎皮質機能抑制の検討
- 外用コルチコステロイド経皮吸収による副腎皮質機能抑制の検討--0.05%Fluocinonide軟膏単純塗布の場合
- ガイヨウ コルチコステロイド ケイヒ キュウシュウ ニヨル フクジン ヒシツ
- —Observations on 0.05% Fluocinonide Ointment Applied under Simple Method—
- ―0.05%Fluocinonide軟膏単純塗布の場合―
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Description
Five patients with psoriasis or eczema were treated for 7 consecutive days with 0.05% fluocinonide ointment 30∼60g daily (15∼30mg fluocinonide), and the serum 11-OHCS levels and the urinary 17-OHCS levels were estimated every day. Eosinophil counts and blood glucose levels were also estimated. The serum 11-OHCS levels were apparently lowered in one case with exfoliative dermatitis and slightly lowered in three cases with psoriasis vulgaris. The urinary 17-OHCS levels were not lowered in most cases. Decreasing of eosinophil counts were observed in two cases with eczematous dermatitis and exfoliative dermatitis. Increasing tendency of blood glucose were not observed. The clinical effect was almost equal with some other steroids. The results indicate that the use of 0.05% fluocinonide ointment 30-60g daily results in percutaneous absorption of fluocinonide to cause inhibition of adrenocortical function, though which is slightly, in patients with psoriasis or eczema.
Journal
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- The Nishinihon Journal of Dermatology
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The Nishinihon Journal of Dermatology 38 (2), 278-285, 1976
Western Division of Japanese Dermatological Association
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Details 詳細情報について
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- CRID
- 1390001204300484864
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- NII Article ID
- 130004830438
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- NII Book ID
- AN00183881
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- ISSN
- 18804047
- 03869784
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- NDL BIB ID
- 1707930
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL Search
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed
