Two Cases of Tuberculid (Penis Tuberculid and Erythema Induratum Bazin).

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  • 結核疹の２例（陰茎結核疹・バザン硬結性紅斑）　　ＰＣＲ法を用いた結核菌ＤＮＡ断片の検出
  • —PCR法を用いた結核菌DNA断片の検出—

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We herein report two cases of tuberculid, one patient with penis tuberculid and another with erythema induratum Bazin. Case 1: a 44-year-old Japanese man with no history of tuberculosis, presented with an ulcer and induration on his penis. The patient was treated with minocycline. Case 2: a 57-year-old Japanase man with a past history of lung tuberculosis, presented with ulcerating plaques and indurations occuring on his lower limbs. The patient was treated with a double anti-tuberculosis regime, isoniazid and rifampicin. No mycobacterial DNA was identified from both cases of skin lesions based on an amplification of the specific DNA sequences using the polymease chain reaction (PCR) with formalin-fixed and paraffin-embedded tissues. We also reviewed previous reports of cutaneous tuberculosis and tuberculid including a DNA analysis and discuss the results. Eight patients (100%) of scrofuloderma and 3/3 patients of lupus vulgaris were positive based on the PCR assay. However, only one out of 4 patients with erythema induratum Bazin, 0/2 cases of papulonecrotic tuberculid, and no patients of penis tuberculid (0/2) were positive.

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