Long-term Follow-up of a Case of Xeroderma Pigmentosum Complementation Group F

  • ASAI Misachi
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences
  • KOIKE Yuta
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences
  • TOMIMURA Saori
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences
  • TAKENAKA Motoi
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences
  • UTANI Atsushi
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences

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Other Title
  • 長期観察中の色素性乾皮症 F 群の 1 例
  • 症例 長期観察中の色素性乾皮症F群の1例
  • ショウレイ チョウキ カンサツ チュウ ノ シキソセイ カンピショウ Fグン ノ 1レイ

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Abstract

Xeroderma pigmentosum (XP) is associated with a deficient mechanism for repair of ultraviolet light-induced damage of DNA. The disease includes eight genetically different complementation groups comprising XP-A through-G and the XP variant (XP-V). We report on an 83-year-old man with XP group F (XP-F) disease. He had been sensitive to sunlight since childhood and had pigmentation changes in sun-exposed skin. He was diagnosed as XP-F at the age of 64 years. Despite avoiding sunlight exposure since the diagnosis by using sunscreen or wearing long-sleeved shirts, he developed two squamous cell carcinomas, one basal cell carcinoma and 14 actinic keratoses in the sun-exposed skin during almost 20 years of observation at our hospital. These observations suggest that early diagnosis of XP is important in order to prevent XP-F patients from developing skin cancers.

Journal

  • Nishi Nihon Hifuka

    Nishi Nihon Hifuka 75 (6), 508-510, 2013

    Western Division of Japanese Dermatological Association

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