Long-term Follow-up of a Case of Xeroderma Pigmentosum Complementation Group F
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- ASAI Misachi
- Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences
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- KOIKE Yuta
- Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences
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- TOMIMURA Saori
- Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences
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- TAKENAKA Motoi
- Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences
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- UTANI Atsushi
- Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences
Bibliographic Information
- Other Title
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- 長期観察中の色素性乾皮症 F 群の 1 例
- 症例 長期観察中の色素性乾皮症F群の1例
- ショウレイ チョウキ カンサツ チュウ ノ シキソセイ カンピショウ Fグン ノ 1レイ
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Description
Xeroderma pigmentosum (XP) is associated with a deficient mechanism for repair of ultraviolet light-induced damage of DNA. The disease includes eight genetically different complementation groups comprising XP-A through-G and the XP variant (XP-V). We report on an 83-year-old man with XP group F (XP-F) disease. He had been sensitive to sunlight since childhood and had pigmentation changes in sun-exposed skin. He was diagnosed as XP-F at the age of 64 years. Despite avoiding sunlight exposure since the diagnosis by using sunscreen or wearing long-sleeved shirts, he developed two squamous cell carcinomas, one basal cell carcinoma and 14 actinic keratoses in the sun-exposed skin during almost 20 years of observation at our hospital. These observations suggest that early diagnosis of XP is important in order to prevent XP-F patients from developing skin cancers.
Journal
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- Nishi Nihon Hifuka
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Nishi Nihon Hifuka 75 (6), 508-510, 2013
Western Division of Japanese Dermatological Association
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Details 詳細情報について
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- CRID
- 1390001204301049216
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- NII Article ID
- 130004831839
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- NII Book ID
- AN00183881
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- ISSN
- 18804047
- 03869784
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- NDL BIB ID
- 025069595
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed