Pityriasis Rubra Pilaris : Failure of Treatment with Infliximab

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  • Infliximab が無効であった毛孔性紅色粃糠疹の 1 例
  • 症例 Infliximabが無効であった毛孔性紅色粃糠疹の1例
  • ショウレイ Infliximab ガ ムコウ デ アッタ ケアナセイ ベニイロヒヌカシン ノ 1レイ

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Abstract

A 45-year-old man presented with erythema on the cheek. He was treated with topical steroids, cyclosporine, etretinate and oral corticosteroids. However, since his symptoms did not improve, his medication was discontinued. A physical examination revealed erythroderma and scaly erythema on his palms. Histology of a biopsy specimen from an erythema on his shoulder demonstrated a compact orthokeratosis alternating with parakeratosis in vertical and horizontal arrays and superficial acantholysis with dyskeratosis reminiscent of pemphigus. The clinical and histopathological findings were consistent with pityriasis rubra pilaris. His symptoms did not improve after administration of three infusions of infliximab at 5 mg/kg/dose, which was then discontinued. Pityriasis rubra pilaris is an uncommon papulosquamous disorder with clinical and histological parallels to psoriasis. Treatment with tumor necrosis factor antagonists is currently being investigated and some results have been reported. Here we present a case of idiopathic classic adult pityriasis rubra pilaris unresponsive to infliximab.

Journal

  • Nishi Nihon Hifuka

    Nishi Nihon Hifuka 76 (4), 349-352, 2014

    Western Division of Japanese Dermatological Association

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