Squamous Cell Carcinoma Arising within Lichen Planus of the Vulva

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  • KANNO Miyuki
    Department of Dermatology, Faculty of Medicine, University of Miyazaki
  • NARITA Yukiyo
    Department of Dermatology, Faculty of Medicine, University of Miyazaki
  • MOCHIDA Kosuke
    Department of Dermatology, Faculty of Medicine, University of Miyazaki
  • AMANO Masahiro
    Department of Dermatology, Faculty of Medicine, University of Miyazaki

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Other Title
  • 女性外陰部の扁平苔癬に生じた有棘細胞癌の 1 例
  • 症例 女性外陰部の扁平苔癬に生じた有棘細胞癌の1例
  • ショウレイ ジョセイ ガイインブ ノ ヘンペイ タイセン ニ ショウジタ ユウキョクサイボウガン ノ 1レイ

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Abstract

We reported a case of squamous cell carcinoma (SCC) arising within lichen planus (LP) of the vulva. A 51-year-old woman had suffered from vulval pruritus for 10 years, and an erosion appeared at the same site 2 years ago. At the first medical examination, white spots and erosions were observed on the bilateral labium minus. Histopathological examination showed LP on the left labium minus. Vulval LP had been intractable, and ulcers appeared within the erosive areas. Oral prednisolone (5 mg/day) for vulval LP failed to heal the ulcers. Three years later, biopsy of the ulcer within LP revealed a SCC. Resection with a 6 mm surgical margin from the LP and biopsy of sentinel lymph nodes were performed. Histopathology of the excised tumor revealed atypical keratinocytes that had invaded into the dermis, and vascular invasion was also identified. The bilateral inguinal sentinel lymph nodes were free of tumor cells. At 1 year after the operation, neither recurrence nor metastasis has been observed. LP-associated SCC has a poor prognosis, with high rates of regional lymph node metastases, recurrence, and disease-related death. An adequate treatment for LP lesions is important for preventing the development of SCC.

Journal

  • Nishi Nihon Hifuka

    Nishi Nihon Hifuka 78 (3), 257-261, 2016

    Western Division of Japanese Dermatological Association

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