Verification of Exacerbating Factors of Atopic Dermatitis

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  • アトピー性皮膚炎悪化因子の検証：汗と温度に関する最近の知見
  • アトピーセイ ヒフエン アッカ インシ ノ ケンショウ : アセ ト オンド ニ カンスル サイキン ノ チケン

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Abstract

Sweat and warmth have been thought to implicate in exacerbate atopic dermatitis in diverse ways. Cause of both attenuated sweating and increased warmth-induced pruritus in atopic dermatitis remains obscure. Such situation makes the education for patients difficult. Thus, we scientifically verified how these factors influence symptoms of atopic dermatitis. As for sweating, the impact of histamine to acethylcholine-induced sweating response was measured with counting the number of active sweat gland by starch-iodin reaction, dynamic optical coherence tomography, visualizing sweat by twophoton excitation fluorescence microscopy, and quantitative sudomotor axon reflex test. Histamine demonstrably inhibited the acethylcholine-induced sweating in both murine and human via H1 receptor-mediated signaling. As for These results might provide basis for understanding pathogenesis and formulating novel therapeutic approach of anhidrosis in atopic dermatitis.

Journal

  • Nishi Nihon Hifuka

    Nishi Nihon Hifuka 76 (3), 189-193, 2014

    Western Division of Japanese Dermatological Association

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