Eosinophilic Pustular Folliculitis with Elevation of Serum IgE in an Elderly Patient

UEO Daisuke, YAMAGUCHI Tomiko, MASUDA  Mitsuru, HATANO Yutaka, FUJIWARA  Sakuhei

doi:10.2336/nishinihonhifu.77.556

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高 IgE 血症を呈し，最高齢で発症した好酸球性膿疱性毛包炎の 1 例
症例高IgE血症を呈し,最高齢で発症した好酸球性膿疱性毛包炎の1例
ショウレイコウIgE ケツショウオテイシ,サイコウレイデハッショウシタコウサンキュウセイノウホウセイモウホウエンノ 1レイ

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Abstract

We report on an 82-year-old man who had pneumoconiosis. He presented with a 1-year history of pruritic indurated erythematous plaques studded with pustules on the face, which extended thereafter to the trunk at the age of 80. This is the most elderly patient ever reported to show these symptoms. A histological examination revealed eosinophilic infiltration around the hair follicles and sebaceous glands. Thus, the diagnosis of eosinophilic pustular folliculitis (EPF) was made. Oral indomethacin at a dose of 50 mg per day relieved his skin lesions, but the lesions relapsed after reduction of the dose to 25 mg per day. Oral minocycline at a dose of 200 mg per day was not effective. Serum IgE was elevated markedly after development of the skin lesions, suggesting that severe EPF maintained for a long period might cause a raised level of IgE. We considered that an adverse drug reaction might have induced EPF in this case, due to the sudden onset of the eruptions and the blood hypereosinophilia.

Journal

Nishi Nihon Hifuka

Nishi Nihon Hifuka 77 (6), 556-560, 2015

Western Division of Japanese Dermatological Association

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