Clinical Efficacy of Loratadine for Chronic Urticaria Refractory to Other Antihistamines

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  • 他抗ヒスタミン薬で効果不十分な慢性蕁麻疹患者に対するロラタジンの臨床的有用性の検討

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The efficacy of loratadine (Claritin®) was evaluated by using Urticaria Activity Score (UAS), Visual Analogue Scale (VAS), and Dermatology Life Quality Index (DLQI) in 18 adult patients with chronic urticaria who showed insufficient relief with other antihistamines. After taking loratadine 10 mg/day for 2 weeks, 12 patients who had a severity of urticaria under level 2 continued to take loratadine 10 mg/day for 2 weeks, and six patients who had a severity score over level 3 were treated with 20mg/day of loratadine for 2 weeks. UAS and VAS scores of the 18 patients were significantly decreased at the 4 weeks endpoint. The total DLQI score was significantly decreased at 4 weeks, indicating that the QOL of patients with chronic urticaria was improved by loratadine administration. No cases with itching lasting for more than 2 hours were observed after 4 weeks. It appears that loratadine administration is useful for patients with chronic urticaria who have shown insufficient reliefwith other antihistamines.

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