Primary Amelanotic Melanoma of the Palm

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  • MATSUNAGA Kayoko
    Department of Dermatology, Fujita-Gakuen University School of Medicine
  • SAKAI Katsuhiko
    Department of Dermatology, Fujita-Gakuen University School of Medicine
  • HIRAMATSU Mitsuyoshi
    Department of Dermatology, Fujita-Gakuen University School of Medicine
  • YAZAKI Kisaku
    Department of Dermatology, Fujita-Gakuen University School of Medicine
  • UEDA Hiroshi
    Department of Dermatology, Fujita-Gakuen University School of Medicine

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Other Title
  • 手掌に原発したAmelanotic Melanoma
  • シュショウ ニ ゲンパツシタ Amelanotic Melanoma

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Abstract

In a 48-year-old woman with primary amelanotic melanoma of the left palm resembling tylosis clinically and nevus of large spindle and/or epithelioid cells pathologically, electron microscopy showed stage III melanosomes in the cytoplasm of the tumor cells. Histologically, the tumor cells formed alveolar structure or nests at the dermo-epidermal junction and showed pagetoid phenomenon to the upper epidermis and to the lateral or radial individual cell extension. Most of the tumor cells lacked melanin pigment on light microscope. A large number of giant cells, telangiectasis and edema of the dermal papilla made it difficult to differentiate this melanoma from nevus of large spindle and/or epithelioid cells. Differentiation between these two melanocytic lesions were discussed on the basis of the related literature.

Journal

  • Nishi Nihon Hifuka

    Nishi Nihon Hifuka 42 (5), 791-795, 1980

    Western Division of Japanese Dermatological Association

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