Delayed Anaphylaxis after Eating Beef Likely Due to IgE Antibody Specific for Galactose-α-1, 3-galactose

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  • HONDA Yumi
    Department of Dermatology, Kochi Medical School, Kochi University
  • YAMAMOTO Mayuko
    Department of Dermatology, Kochi Medical School, Kochi University
  • NAKAJIMA Kimiko
    Department of Dermatology, Kochi Medical School, Kochi University
  • CHINUKI Yuko
    Department of Dermatology, Shimane University Faculty of Medicine
  • SANO Shigetoshi
    Department of Dermatology, Kochi Medical School, Kochi University

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Other Title
  • 牛肉による遅発型アナフィラキシー
  • 症例 牛肉による遅発型アナフィラキシー
  • ショウレイ ギュウニク ニ ヨル チハツガタ アナフィラキシー

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Description

A 67-year-old Japanese man experienced 4 episodes of delayed anaphylaxis between March, 2012 and October, 2013. Delayed anaphylactic attacks occurred several hours after eating egg-bearing flatfish or beef. The skin prick allergen test was positive for beef, pork, and cow's milk. Moreover, CAP-RAST testing revealed the presence of IgE antibodies specific to beef, pork, cow's milk, and dandruff of cat and dog. Western blotting analysis using the patient's sera showed a putative IgE with high affinity for the 50-kDa protein of the mouse chimeric antibody, cetuximab, which contains the oligosaccharide galactose-α-1, 3-galactose (α-gal), a common epitope for the delayed anaphylaxis response to beef meat. Since the patient lived in an area where Japanese spotted fever, for which a tick bites are a cause, is endemic, he might have a history of unnoticed tick bites that sensitized him to α-gal. Furthermore, we speculate that some medicines including aspirin might lower the threshold for exposure to this allergen above which anaphylactic symptoms occur.

Journal

  • Nishi Nihon Hifuka

    Nishi Nihon Hifuka 77 (5), 453-455, 2015

    Western Division of Japanese Dermatological Association

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