HLA-DRB1 Polymorphism of Balopa Islanders in Papua New Guinea

  • Tarasenko Olga
    Department of Chemical Engineering, Chemistry, and Materials Science, Polytechnic University
  • Ohashi Jun
    Department of Human Genetics, Graduate School of Medicine, University of Tokyo
  • Ataka Yuji
    Research Center for Tropical Infectious Diseases, Institute of Tropical Medicine, Nagasaki University
  • Inaoka Tsukasa
    Department of Environmental Sociology, Faculty of Agriculture, Saga University
  • Ohtsuka Ryutaro
    Department of Human Ecology, Graduate School of Medicine, University of Tokyo
  • Tokunaga Katsushi
    Department of Human Genetics, Graduate School of Medicine, University of Tokyo

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Perelik, Solang, and Mouk villages are located in Balopa islands of Papua New Guinea (PNG). It is known that languages spoken in Balopa belong to the same family of Austronesian languages, but the language of Mouk is different from others at a sub-family level. Most of Balopa islanders have subsisted mainly on horticulture and reef fishing, while Mouk villagers have depended on fishing and trading. In order to investigate the genetic similarities among Balopa islanders and their affinities to other Oceanian populations, HLA-DRB1 polymorphism was investigated in 98 individuals living in Perelik, Solang, and Mouk. The predominant HLA-DRB1 alleles in Balopa islands were HLA-DRB1*1502 and *1101. Interestingly, Mouk showed a similar distribution of DRB1 alleles to Solang despite their different language and subsistence. Genetic distance calculations and correspondence analysis based on DRB1 allele frequencies suggested that Balopa islanders genetically belong to Austronesians in Melanesia and are distant from other Austronesians in Micronesia or Polynesia.

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