Examination Regarding the Simple Suspension Method using Oral Anticancer Drugs
-
- Murakami Masahiro
- Section of Clinical Pharmaceutics, School of Pharmacy, Hyogo University of Health Sciences
-
- Ikemoto Yoshihiko
- Section of Clinical Pharmaceutics, School of Pharmacy, Hyogo University of Health Sciences
-
- Toya Narumi
- Section of Clinical Pharmaceutics, School of Pharmacy, Hyogo University of Health Sciences
-
- Paku Mihi
- Section of Clinical Pharmaceutics, School of Pharmacy, Hyogo University of Health Sciences
-
- Okuyama Miyuki
- Section of Clinical Pharmaceutics, School of Pharmacy, Hyogo University of Health Sciences
-
- Hatakeyama Kazuko
- Section of Clinical Pharmaceutics, School of Pharmacy, Hyogo University of Health Sciences
-
- Katsuragi Satoko
- Section of Clinical Pharmaceutics, School of Pharmacy, Hyogo University of Health Sciences
-
- Ohno Masako
- Section of Clinical Pharmaceutics, School of Pharmacy, Hyogo University of Health Sciences
-
- Hichiya Hiroyuki
- The Yokohama University of Pharmacy
-
- Zamami Yoshito
- School of Pharmacy, Okayama University
-
- Muro Chikaaki
- Department of Pharmacy, The Hospital of Hyogo College of Medicine
-
- Kimura Takeshi
- Department of Pharmacy, The Hospital of Hyogo College of Medicine
-
- Kurata Naomi
- School of Pharmacy, Showa University
-
- Amano Manabu
- Section of Clinical Pharmaceutics, School of Pharmacy, Hyogo University of Health Sciences
Bibliographic Information
- Other Title
-
- 経口抗がん薬における簡易懸濁法の適応可否に関する検討
Search this article
Abstract
To administer oral anticancer drugs safely, the simple suspension method has been introduced in many hospitals. Therefore, concerning drugs for which it is unclear whether or not this method is applicable, testing must be able to be conducted at any time. In this study, we investigated 20 oral anticancer drugs to expand information on the application of the simple suspension method. Disintegration/suspension and permeability tests were conducted, as described in the 3rd version of the Tube Administration Handbook for Oral Drugs. All products were disintegrated/suspended after 10 minutes. On permeability tests, there was no residue in any tube for tubal feeding. On the final evaluation, the products were regarded as suitable (grade 1). Bicalutamide tablets (80 mg, TCK and KN), which were analyzed in this study, were regarded as suitable (grade 1) on the final evaluation. On the other hand, the simple suspension method is not applicable for a brand-name drug, Casodex® tablets (80 mg). This may be related to the different additives. Furthermore, the results suggest that, even when the simple suspension method is not applicable for a brand-name drug, it may become applicable for generic drugs. This may provide a new merit for promoting the use of generic drugs.
Journal
-
- Japanese Journal of Social Pharmacy
-
Japanese Journal of Social Pharmacy 35 (1), 34-37, 2016
Japanese Society of Social Pharmacy
- Tweet
Details 詳細情報について
-
- CRID
- 1390001204324588288
-
- NII Article ID
- 130005163131
-
- ISSN
- 21882754
- 09110585
-
- Text Lang
- ja
-
- Data Source
-
- JaLC
- CiNii Articles
-
- Abstract License Flag
- Disallowed