Long-term Clinical Evaluation of Intra-arterial Chemotherapy for the Treatment of Recurrent Glottis Cancer after Radiation

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  • 放射線治療後の声門癌再発例に対する超選択的動注化学療法の検討
  • ホウシャセン チリョウ ゴ ノ セイモンガン サイハツレイ ニ タイスル チョウセンタクテキドウ チュウ カガク リョウホウ ノ ケントウ

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Abstract

<p>Objectives: We reviewed a study of superselective intra-arterial and systemic chemotherapy for the treatment of recurrent glottis cancer after radiation performed between 2007 and 2009 to evaluate the long-term survival and preservation of organ function after treatment.</p><p>Subjects and Methods: The patients averaged 70.8 years of age, ranging from 59 to 82 years. One patient had stage Ib disease, three had stage II disease, and one had stage IV disease. All the patients underwent two cycles of superselective intra-arterial docetaxel (40 mg/m2) infusion and subsequently four cases underwent systemic cisplatin (50 mg/m2) and 5-FU (350 mg/m2) chemotherapy. The treatment effects and organ function were then observed during a long follow-up period.</p><p>Results: The observation period lasted for 8–102 months (average, 77.6 months). No major complications were observed. Three cases had a CR, one case had an NC, and one case had a PD. In the case with PD, histopathological examinations revealed the transformation of squamous cell carcinoma into spindle cell carcinoma. This patient died 8 months after treatment. Two cases required a total laryngectomy. One case subsequently underwent seven laser surgeries and a partial laryngectomy and eventually died. The swallow function remained almost unchanged in all the patients. The two CR cases were able to speak well after treatment.</p><p>Conclusion: We concluded that this therapy is safe and is as useful as other treatment modalities for long-term organ preservation and the maintenance of function.</p>

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