FACTORS INFLUENCING UPON THE INCIDENCE OF SEED MIGRATION IN I-125 SEED TRANSPERINEAL PROSTATE IMPLANTATION

DOI 13 References
  • ITAMI Jun
    Department of Radiation Therapy and Oncology, International Medical Center
  • ONISHI Kayoko
    Department of Radiation Therapy and Oncology, International Medical Center
  • KANEMURA Mikio
    Department of Department of Urology, International Medical Center
  • KANAI Kazuyoshi
    Department of Radiation Therapy and Oncology, International Medical Center
  • KONO Yuzuru
    Department of Radiation Therapy and Oncology, International Medical Center
  • FUSE Masashi
    Department of Radiation Therapy and Oncology, International Medical Center
  • NAOI Kuniji
    Department of Radiation Therapy and Oncology, International Medical Center
  • KIYODUKA Makoto
    Department of Radiation Therapy and Oncology, International Medical Center
  • HARA Ryusuke
    Department of Radiation Therapy and Oncology, International Medical Center
  • OKANO Yoshinori
    Department of Department of Urology, International Medical Center
  • MINOWADA Shigeru
    Department of Department of Urology, International Medical Center

Bibliographic Information

Other Title
  • 経会陰的前立腺I-125小線源治療におけるシード線源移動に及ぼす因子の検討

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Description

Objective: Transperineal I-125 seed brachytherapy for prostate cancer is rapidly expanding in Japan. Seed migrations to lung and abdomen are well known complication in the seed brachytherapy. The rate of incidence and the predisposing factors were studied.<br>Material and Method: From April 2004 through January 2005, 36 patients underwent transperineal I-125 seed brachytherapy for prostate cancer. In all patients loose I-125 seeds were inserted with Mick applicator according to modified peripheral loading pattern. One day, 1 week, and 1 month after the procedure, posteroanterior and lateral chest X-rays and abdominal X-ray were performed.<br>Results: Abdominal and chest seed migrations were seen in 11 (30.6%) and 14 (38.9%) patients, respectively. In total, 20 patients (55.6%) showed seed migrations. Forty-two I-125 seeds migrated out of 2,508 implanted seeds. Most of the migrations were seen until 1 month after the procedure. The preplanned number of the extraprostatic seeds had a statistically significant influence upon the incidence of seed migration.<br>Conclusions: Seed migration is not a rare phenomenon in transperineal I-125 seed brachytherapy for prostate cancer. To confirm seed migration, X-ray examinations 1 month after the procedure are suited. At the preplanning, the number of extraprostatic seeds should be limited to minimal to decrease the incidence of seed migration. In future, the introduction of linked I-125 seeds is preferred.

Journal

  • The Journal of JASTRO

    The Journal of JASTRO 17 (2), 109-113, 2005

    Japanese Society for Therapeutic Radiology and Oncology

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