Increase in the Level of TIMP-1 in Saliva by Oral Administration of Zinc in Patients with Taste Disorder Due to Zinc Deficiency

DOI 22 References
  • Monya Mitsunori
    Department of Oral Biological Science Niigata University Graduate School of Medical and Dental Science
  • Igarashi Atsuko
    Department of Oral Biological Science Niigata University Graduate School of Medical and Dental Science
  • Asatsuma Masumi
    Department of Oral Biological Science Niigata University Graduate School of Medical and Dental Science
  • Watanabe Mamoru
    Department of Oral Biological Science Niigata University Graduate School of Medical and Dental Science
  • Takeishi Hideyuki
    Department of Oral Biological Science Niigata University Graduate School of Medical and Dental Science
  • Nomura Shuichi
    Department of Oral Health and Science Niigata University Graduate School of Medical and Dental Science

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Other Title
  • 亜鉛不足が原因の味覚障害患者に亜鉛の経口投与で唾液中のTIMP-1 (tissue inhibitor of metalloproteinase-1)

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Abstract

We have already reported that the levels of TIMP-1 (Tissue inhibitor of metalloproteinase) in saliva and Zn2+ in serum were significantly lower in patients with taste disorder than in healthy subjects. This decrease in the level of TIMP-1 was often accompanied by a decrease of zinc in serum. In this study, to test whether administration of zinc is effective in the taste disorder and to establish a method for diagnosis, we have measured and compared TIMP-1 level in saliva before and after treatment for patients with taste disorder. Seven patients (aged 52-82 years) who presented with hypoguesia or loss of taste and were suspected of having zinc deficiency were selected. In these patients, saliva which was secreted by stimulation for 5 minutes was collected and its supernatant was used as the sample to determine TIMP-1 level by Sandwich-Enzyme-Immunoassay (Sandwich EIA) system. The level of TIMP-1 was 130.7±S .D. 57.4ng/ml before treatment and 192.2±S.D. 42.6 ng/ml after treatment (resolution of symptoms), showing a significant difference (p<0.01). These results indicate that taste disorder due to zinc deficiency (including latent zinc deficiency) was related to the decrease of TIMP-1 level in saliva and this was improved by the treatment with zinc administration. Improved symptoms were confirmed by the gustatory test.

Journal

  • Ronen Shika Igaku

    Ronen Shika Igaku 18 (1), 3-9, 2003

    Japanese Society of Gerodontology

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