A case of angioimmunoblastic T-cell lymphoma with bone marrow involvement, polyclonal hypergammaglobulinemia and skin rash

DOI 1 Citations 21 References
  • SUZUKI Norihiro
    <i>Department of Dermatology, Okayama University School of Medicine</i>
  • SUZUKI Daisuke
    <i>Department of Dermatology, Okayama University School of Medicine</i>
  • FUJITA Atsushi
    <i>Department of Dermatology, Okayama University School of Medicine</i>
  • NOMURA Chiyo
    <i>Department of Dermatology, Okayama University School of Medicine</i>
  • FUJII Kazuyasu
    <i>Department of Dermatology, Okayama University School of Medicine</i>
  • TSUJI Kazuhide
    <i>Department of Dermatology, Okayama University School of Medicine</i>
  • YAMASAKI Osamu
    <i>Department of Dermatology, Okayama University School of Medicine</i>
  • ONO Takashi
    <i>Department of Dermatology, Okayama University School of Medicine</i>
  • IWATSUKI Keiji
    <i>Department of Dermatology, Okayama University School of Medicine</i>

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Other Title
  • 中毒疹様皮疹，多クローン性高ガンマグロブリン血症，骨髄浸潤を伴ったangioimmunoblastic T－cell lymphomaの1例

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An 85-year-old man presented with a one-month history of generalized skin rash associated with continuous low-grade fever and sweating at night. A skin biopsy specimen showed a nonspecific finding of perivascular dermatitis. Laboratory findings revealed mild anemia, polyclonal hypergammaglobulinemia, and elevated levels of C-reactive protein, erythrocyte sedimentation rate and soluble interleukin-2 receptor. No serological abnormalities were found for HTLV-1 or EBV. Computed tomography findings showed generalized lymphadenopathy and mild splenomegaly. Histological findings of the inguinal lymph node showed destructive proliferation of CD4 and CD45RO positive atypical medium-sized lymphocytes associated with angiogenesis. Southern blot analysis detected a clonal rearrangement of T-cell receptor Cβ1 genes. Bone marrow aspiration revealed infiltration of lymphocytes with the same phenotype as those of the tumor cells in the lymph node. Based on these findings, a diagnosis of angioimmunoblastic T-cell lymphoma with bone marrow involvement (stage IV) was made.[Skin Cancer (Japan) 2011 ; 26 : 134-138]

Journal

  • Skin Cancer

    Skin Cancer 26 (2), 134-138, 2011

    The Japanese Skin Cancer Society

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