Microinvasion

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  • Paget病micro invasion

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The microinvasive stage of Paget's disease is defined as proliferation of solitary or a small group of cancer cells in the subepidermal layer of the dermis. It is important to recognize this stage of the disease in order to anticipate the prognosis of the patients and to select the most suitable treatment. Key features to differentiate microinvasion of the disease with oblique cut pathology preparations are the absence of basal layer around the tumor nests, dense staining of the tumor cells, focally grouped or band like proliferation of tumor cells devoid of spiral or linear configuration and smaller size of the tumor cells compared with those in the epidermis. [Skin Cancer (Japan) 2008; 23: 332-337]

Journal

  • Skin Cancer

    Skin Cancer 23 (3), 332-337, 2008

    The Japanese Skin Cancer Society

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