Malignant peripheral nerve sheath tumor in an NF1 patient treated with sorafenib, a case report

DOI 1 Citations 5 References
  • YOKOI Ikumi
    <i>Department of Dermatology, Kagawa University School of Medicine</i>
  • ISHIKAWA Emiko
    <i>Department of Dermatology, Kagawa University School of Medicine</i>
  • HOSOKAWA Yoichiro
    <i>Department of Dermatology, Kagawa University School of Medicine</i>
  • MORIUE Junko
    <i>Department of Dermatology, Kagawa University School of Medicine</i>
  • KOGURE Tetsukuni
    <i>Department of Plastic Surgery, Kagawa University School of Medicine</i>
  • TANAKA Yoshio
    <i>Department of Plastic Surgery, Kagawa University School of Medicine</i>
  • IKEDA Masami
    <i>Department of Dermatology, Japanese Red Cross Takamatsu Hospital</i>
  • KUBOTA Yasuo
    <i>Department of Dermatology, Kagawa University School of Medicine</i>

Bibliographic Information

Other Title
  • 多発転移に対してソラフェニブ（ネクサバール<sup>®</sup>）で加療するも急激な転帰をとった悪性末梢神経鞘腫（Malignant peripheral nerve sheath tumor，MPNST）の1例

Abstract

We report a case of a 49-year-old female with malignant peripheral nerve sheath tumor (MPNST) in neurofibromatosis1. There were multiple neurofibromas on her whole body, and two larger subcutaneous tumors on her back and left axilla. Because these two tumors had been developing over the course of several months and she felt pain, the tumors were resected. The pathological diagnosis of the tumor on her back was MPNST, and that on her left axilla was related lymph node metastasis. PET-CT revealed multiple bone and lymph nodes metastases. Three courses of adjuvant chemotherapy with adriamycin and ifosfamide were not effective. We started oral administration of 800 mg of sorafenib daily but the metastatic tumors were enlarging. The sorafenib was discontinued because of liver disfunction on the 48th day from the start of medication. Afterwards, the metastatic tumor had expanded more rapidly, and she died of multiple organ failure two months after the discontinuance of sorafenib.[Skin Cancer (Japan) 2011 ; 26 : 337-341]

Journal

  • Skin Cancer

    Skin Cancer 26 (3), 337-341, 2011

    The Japanese Skin Cancer Society

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Keywords

Details 詳細情報について

  • CRID
    1390001204335979264
  • NII Article ID
    130002149390
  • DOI
    10.5227/skincancer.26.337
  • ISSN
    18843549
    09153535
  • Text Lang
    ja
  • Data Source
    • JaLC
    • Crossref
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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