頬部ｌｏｗ‐ｇｒａｄｅ　ｍｙｘｏｆｉｂｒｏｓａｒｃｏｍａの１例

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  • Low-grade myxofibrosarcoma of the cheek

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A 45-year-old man visited a local physician with a one-year history of an asymptomatic subcutaneous nodule on his left cheek. A skin punch biopsy was taken, and the findings led to probable diagnosis of myxofibrosarcoma. He was referred to our hospital for evaluation and management. On his initial visit, physical examination revealed a skin-colored, elastic-soft, well-demarcated nodule on his left cheek, 4.5×3.5cm in size. We performed wide local excision and the defect was reconstructed by a cervicofacial flap. The patient was well and remained disease-free at 9 months follow-up.<br>A histopathological examination revealed a fairly well-defined mass in the subcutaneous tissue. The tumor was characterized by a proliferation of sparsely distributed cells which had slightly atypical, rounded or spindle nuclei, curvilinear, thin-walled blood vessels, and myxoid stroma. Immunohistochemically, these tumor cells were positive for CD68 and negative for alpha-smooth muscle actin, desmin, S-100 protein and cytokeratin. [Skin Cancer (Japan) 2008; 23: 22-26]

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