悪性黒色腫肝転移に対してシスプラチン動注療法を施行した１例

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  • A case of liver metastases of malignant melanoma with hepatic arterial injection of cisplatin

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A 51-year-old female noticed a red-colored elevated tumor that had first appeared on her left femoral region at the age of 20. Thirty-one years later, the lesion was removed by plastic surgery at our hospital. After the excised tumor was diagnosed as a malignant melanoma, she consulted our department.<br>After an enlargement operation and lymphadenectomy, DAV-Feron and D-Feron chemotherapy were administered to her. Nine months later after the enlargement operation, we discovered metastatic tumors of the liver and skin. Arterial injection of cisplatin was given to combat the liver metastases, while local INF-gamma therapy was given for the metastatic tumors of the skin. Treatment with 70 mg/m2/M cisplatin by arterial injection remarkably reduced the volumes of the liver and skin tumors. The side effects, however, were severe, requiring a reduction of the cisplatin dose to 7 mg/m2/2W. As a consequence, the metastatic tumors of the skin proliferated. Then, treatment had to be interrupted, due to the secondary infection of an ileus. The patient later died from disseminated intravascular coagulation (DIC) and brain metastases.<br>In this instance, CDDP arterial injection therapy contributed to a temporary reduction of the metastatic tumor. Therefore, CDDP arterial injection therapy appears to be effective against liver metastases. [Skin Cancer (Japan) 2006; 21: 18-22]

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