A case of primary cutaneous anaplastic large cell lymphoma with high levels of sIL-2R

DOI
  • TSUNEDA Misako
    Department of Dermatology Toyama Medical and Pharmaceutical University
  • HINO Takayuki
    Department of Dermatology Toyama Medical and Pharmaceutical University
  • TOYODA Masahiko
    Department of Dermatology Toyama Medical and Pharmaceutical University 21<sup>st</sup> Century COE program Toyama Medical and Pharmaceutical University
  • MOROHASHI Masaaki
    Department of Dermatology Toyama Medical and Pharmaceutical University

Bibliographic Information

Other Title
  • sIL-2Rが高値を示した皮膚原発性未分化大細胞リンパ腫

Search this article

Description

We here report a case of an 82-year-old man who had been treated with cyclosporine A for psoriasis, with primary cutaneous anaplastic large cell lymphoma (ALCL) showing high levels of sIL-2R. He noticed rapidly developing subcutaneous tumors on the inguinal lesion and the buttocks during 1 month. Serum levels of sIL-2R remarkably increased although no metastatic lesions were detected. Histological examination revealed a dermal tumor composed mainly of large atypical lymphocytes. Immunohistochemical staining showed that tumor cells were positive with CD30 and EMA, and were negative with CD15, anaplastic lymphoma kinase and EBV-associated antibodies. He was treated with both roentgen ray therapy and a local injection of IFN-γ. Respiratory failure due to pleural metastasis was the leading cause of death 8 months after the initial onset. Levels of sIL-2R may be a prognostic marker of primary cutaneous ALCL because serum levels of sIL-2R correlated with the disease activity in this case. [Skin Cancer (Japan) 2004; 19: 355-358]

Journal

  • Skin Cancer

    Skin Cancer 19 (3), 355-358, 2004

    The Japanese Skin Cancer Society

Keywords

Details 詳細情報について

Report a problem

Back to top