メルケル細胞癌の１例

DOI 被引用文献1件 参考文献26件

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  • A case of Merkel cell carcinoma successfully treated with radiotherapy

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We report a case of recurring Merkel cell carcinoma on the nose of a 90-year-old man. A radical operation was performed on the red nodule on his nose. However, 1 month later a red nodule 30×30mm in diameter was found on his nose and another red nodule 6×7mm in diameter appeared on his right cheek. The biopsy specimen revealed cytokeratin20-positive tumor cells localized in the dermis to subcutaneous fatty tissue. We chose radiotherapy treatment of (5MeV) for both lesions. When the total amount of irradiation reached 66 Gy, the tumor completely disappeared. We reviewed 21 reported cases of radiotherapy treated Merkel cell carcinoma and found a 24% rate of local recurrence. The recurrence cases with prophylactic lymph node radiation were observed only in 10%, whereas the recurrence rate without radiotherapy revealed 45.5%. Local recurrence and lymph node involvement are important prognostic factors. We suggest that adjuvant radiotherapy is very effective for Merkel cell carcinoma. [Skin Cancer (Japan) 2005; 20: 84-88]

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