A malignant peripheral nerve sheath tumor (MPNST) in an NF1 patient, following 2 separate recurrences of a neurofibroma

  • IIOKA Hiroshi
    <i>Department of Dermatology, Nara Medical University</i> <i>Plastic Surgery Center, Nara Medical University</i>
  • OGAWA Kouhei
    <i>Department of Dermatology, Nara Medical University</i>
  • KUWAHARA Masamitsu
    <i>Plastic Surgery Center, Nara Medical University</i>
  • FUKUMOTO Takaya
    <i>Department of Dermatology, Nara Medical University</i>
  • ASADA Hideo
    <i>Department of Dermatology, Nara Medical University</i> <i>Plastic Surgery Center, Nara Medical University</i>

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Other Title
  • 複数回の手術侵襲の既往を有するNF1に発生した悪性末梢神経鞘腫瘍例

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Abstract

We report a case of a 69-year-old-woman with a malignant peripheral nerve sheath tumor in neurofibromatosis 1. Her abdominal neurofibroma was resected in 2003, and the recurrent neurofibroma was resected again in 2007. However, in 2009, it recurred again, and rapidly increased in size. She was referred to our hospital. We resected the tumor, and diagnosed it as low grade MPNST. We carried out radical resection on the rectus abdominal muscle with a 5 cm margin from the scar and reconstructed the skin defect by mesh graft. There has been no evidence of recurrence or metastasis 3 years post operatively. We think that the neurofibroma, which is a benign tumor, might have changed into MPNST, which is a malignant tumor, as a result of several surgeries in this case.[Skin Cancer (Japan) 2013 ; 28 : 74-78]

Journal

  • Skin Cancer

    Skin Cancer 28 (1), 74-78, 2013

    The Japanese Skin Cancer Society

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