Histocompatible Parthenogenetic Embryonic Stem Cells as a Potential Tissue Source for Regenerative Medicine
-
- Yabuuchi Akiko
- Advanced Medical Research Institute of Fertility, Kato Ladies Clinic
-
- Rehman Haniya
- Cancer Biology and Genetics Program, Center for Cell Engineering, Sloan Kettering Institute, Cell and Developmental Biology Graduate program, Weill Medical College of Cornell University
-
- Kim Kitai
- Cancer Biology and Genetics Program, Center for Cell Engineering, Sloan Kettering Institute, Cell and Developmental Biology Graduate program, Weill Medical College of Cornell University
この論文をさがす
抄録
Parthenogenesis is the process in which an oocyte develops into an embryo without fertilization. Parthenogenetic activation can be performed at various stages of meiosis, yielding embryos with distinct genetic patterns of homozygosity and heterozygosity. Parthenogenetic embryonic stem (pES) cells derived from such embryos have heterozygous patterns that can be identified using genome-wide single nucleotide polymorphism (SNP) analysis, to determine whether extrusion of the first or second polar body has been inhibited. Heterozygous pES cells carrying the full complement of major histocompatibility complex (MHC) antigens matched to the oocyte donor may provide a potential source of immune-matched cells and tissues for cell replacement therapy. In this review, we summarize the process of deriving heterozygous MHC-matched pES cells using mouse and human models.<br>
収録刊行物
-
- 日本哺乳動物卵子学会誌
-
日本哺乳動物卵子学会誌 29 (1), 17-21, 2012
日本卵子学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390001204338774656
-
- NII論文ID
- 130004436824
- 40019312239
-
- NII書誌ID
- AN10548943
-
- ISSN
- 13475878
- 13417738
-
- NDL書誌ID
- 023754015
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可