An inhibitory effect of tranexamic acid on ovulation in hamster ovaries incubated in vitro

DOI
  • SANKAI Tadashi
    Department of Veterinary Physiology, College of Agriculture & Veterinary Medicine, Nihon University
  • WATANABE Yasuhiro
    Department of Veterinary Physiology, College of Agriculture & Veterinary Medicine, Nihon University
  • KANAYAMA Kiichi
    Department of Veterinary Physiology, College of Agriculture & Veterinary Medicine, Nihon University
  • ENDO Tuyoshi
    Department of Veterinary Physiology, College of Agriculture & Veterinary Medicine, Nihon University
  • SAKUMA Yuzi
    Department of Veterinary Physiology, College of Agriculture & Veterinary Medicine, Nihon University

Bibliographic Information

Other Title
  • ハムスターの体外培養卵巣におけるtranexamic acidの排卵抑制効果

Description

It is reported as a hypothesis that, in the final stage of ovulation, theplasminogen activator acts on the follicular wall to rupture it up and thus toinduce ovulation. The authors applied the excited ovary to tranexamic acid, which is an anti-plasminogen activator, to examine if it would inhibitovulation. Ovaries were obtained from golden hamsters and incubated in vitro. Tranexamic acid was added to the medium at a concentration of 0.196. Inovaries excited at 21:00 and 23:00 of proestrus of the estrus cycle, ovulationrate was 25.096 and 91.696, and the average numburs of ova ovulated were0.25-0.12 and 1.58±0.26, respectively. The number of ova was significantlyfewer than the control.<BR>In this study, it was clear that tranexamic acid inhibited ovulation fromovaries in vitro. The present results indicated that ovulation in culturedovaries was inhibited by blooking plasminogen activator.

Journal

Details 詳細情報について

  • CRID
    1390001204339147008
  • NII Article ID
    130003839315
  • DOI
    10.14893/jmor1984.4.98
  • ISSN
    18846505
    02895439
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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