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- Furukawa Saiichi
- Laboratory of Applied Genetics, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo 174-0032, Japan
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- Matsuno Yuta
- Laboratory of Applied Genetics, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo 174-0032, Japan
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- Emori Chihiro
- Laboratory of Applied Genetics, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo 174-0032, Japan
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- Fujii Wataru
- Laboratory of Applied Genetics, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo 174-0032, Japan
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- Naito Kunihiko
- Laboratory of Applied Genetics, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo 174-0032, Japan
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- Sugiura Koji
- Laboratory of Applied Genetics, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo 174-0032, Japan
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抄録
Signals from fibroblast growth factors (FGFs) play a critical role in regulating the development of ovarian granulosa cells; however, the expression and regulation of FGF receptors are not well understood. The present study was conducted to assess the expression kinetics of transcripts encoding FGF receptors (FGFRs) during granulosa cell development in mice. In addition, the effects of oocytes on the levels of Fgfr transcripts were examined, as well as the expression of FGFR mRNA expression in porcine granulosa cells. All four types of Fgfr transcripts were detected in cumulus and mural granulosa cells with a tendency toward higher expression levels in mural granulosa cells. Interestingly, the expressions of Fgfr1 and Fgfr2 mRNA in cumulus cells were suppressed by co-culture with oocytes, whereas their expression in mural granulosa cells was promoted. Porcine cumulus cells expressed higher levels of FGFR1 and FGFR2 mRNA than mural granulosa cells. The results show that FGF receptor expression in granulosa cells, at least at the mRNA level, is dynamically regulated during follicular development, and that oocytes participate in the regulation of differential expression between cumulus and mural granulosa cells. Moreover, the regulation of transcripts encoding FGF receptors in granulosa cells may differ between mice and pigs.
収録刊行物
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- 日本哺乳動物卵子学会誌
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日本哺乳動物卵子学会誌 31 (3), 86-92, 2014
日本卵子学会
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詳細情報 詳細情報について
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- CRID
- 1390001204339520640
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- NII論文ID
- 130004704226
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- NII書誌ID
- AN10548943
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- ISSN
- 13475878
- 13417738
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- NDL書誌ID
- 025896102
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- 使用不可