A case of acute tubulointerstitial nephritis and uveitis syndrome with mast cells

DOI 7 References
  • Kondo Shuji
    Department of Pediatrics, University of Tokushima School of Medicine
  • Kagami Shoji
    Department of Pediatrics, University of Tokushima School of Medicine
  • Urushihara Maki
    Department of Pediatrics, University of Tokushima School of Medicine
  • Kitamura Akiko
    Department of Pediatrics, University of Tokushima School of Medicine
  • Satake Nobuo
    Department of 2 ND Pathology, University of Tokushima School of Medicine
  • Izumi Keisuke
    Department of 2 ND Pathology, University of Tokushima School of Medicine
  • Kuroda Yasuhiro
    Department of Pediatrics, University of Tokushima School of Medicine

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  • 肥満細胞浸潤を認めたぶどう膜炎を伴う間質性腎炎症候群の１女児例

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Abstract

  We describe the clinicopathological characteristics of a patient with acute tubulointerstitial nephritis and uveitis syndrome (TINU) with mast cells infiltrating in the interstitium. Repeated biopsies were performed before and after treatment of prednisolone. The pathogenesis of TINU remains unknown, but the T cell-mediated immune response or autoantibodies is considered to be involved. Recently, mast cells have been postulated to play a role in renal interstitial fibrosis. We investigated the localization of mast cells in the biopsy sections by immunohistochemistry. First renal biopsy showed that the mast cells infiltrated into the interstitial fibrotic lesion. Second biopsies showed the number of mast cells is decreased with the improvement of clinical symptoms and pathological lesions. These suggested that mast cells play an important role in the development of renal inerstitial injury in TINU.

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