Kidney regeneration and disease modeling research using iPS cell technology

DOI 35 References
  • Osafune Kenji
    Center for iPS Cell Research and Application (CiRA), Kyoto University

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  • iPS細胞を用いた腎臓再生と新規疾患モデルの作製

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Chronic kidney disease (CKD) causes both medical and medicoeconomical problems worldwide. Regenerative medicine strategies using induced pluripotent stem (iPS) cells are among the candidate approaches to solve the problems. The mechanisms of kidney morphogenesis and cell fate determination of renal lineage cells have been elucidated by using experimental animal models. Based on the knowledge of kidney development, considerable work has already been done towards the generation of renal lineage cells from mouse embryonic stem (ES) cells, whereas few reports have described the research on kidney regeneration using human ES/iPS cells. We have recently established a highly efficient differentiation method from human ES/iPS cells into intermediate mesoderm, an embryonic germ layer that gives rise to most cells constituting adult kidney, with an induction rate of more than 90%. These human intermediate mesoderm cells have the developmental potential to give rise to multiple renal cell types and to form three-dimensional renal tubular structures. Establishing the methods for directed differentiation from human ES/iPS cells into renal lineage cells through the intermediate mesoderm cells will be required for the development of iPS cell technology-based treatments for CKD, such as cell transplantation therapy and new drug discovery by disease modeling research using patient-derived iPS cells from intractable renal disorders.

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