Is anti-CCP antibody useful for prediction of progression to RA in patients with ‘arthralgia’? A 1-year follow-up study of 100 patients with a chief complaint of arthralgia
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- Shibata Tomohiko
- Division of Rheumatology and Allergy, Department of Internal Medicine, St. Marianna University School of Medicine
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- Shibata Toshiko
- Division of Rheumatology and Allergy, Department of Internal Medicine, St. Marianna University School of Medicine
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- Nakano Hiromasa
- Division of Rheumatology and Allergy, Department of Internal Medicine, St. Marianna University School of Medicine
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- Yamasaki Yoshioki
- Division of Rheumatology and Allergy, Department of Internal Medicine, St. Marianna University School of Medicine
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- Okazaki, Takahiro
- Division of Rheumatology and Allergy, Department of Internal Medicine, St. Marianna University School of Medicine
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- Nagafuchi Hiroko
- Division of Rheumatology and Allergy, Department of Internal Medicine, St. Marianna University School of Medicine
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- Yamada Hidehiro
- Division of Rheumatology and Allergy, Department of Internal Medicine, St. Marianna University School of Medicine
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- Ozaki Shoichi
- Division of Rheumatology and Allergy, Department of Internal Medicine, St. Marianna University School of Medicine
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- Yamazaki Satoshi
- Department of Clinical Laboratory, St. Marianna University School of Medicine Hospital
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- Sugiyama Kazuo
- Department of Clinical Laboratory, St. Marianna University School of Medicine Hospital
Bibliographic Information
- Other Title
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- 「関節痛」患者のRA進展予測に抗CCP抗体は有用か? 関節痛を主訴に来院した患者100名の初診時と一年後診断の検討
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Abstract
Many patients visit primary care clinics to seek medical care for arthralgia. Among these patients are those with non-inflammatory diseases, who often get better only by taking rest and/or conservative treatment. If they have inflammatory diseases such as rheumatoid arthritis (RA), however, they should be correctly diagnosed and treated at an early stage. Anti-CCP antibody is an autoantibody specific for RA and is of great help for the diagnosis of RA in ‘arthritis’ patients. The usefulness of anti-CCP antibody in patients with ‘arthralgia’ remains to be clarified in terms of the diagnosis of ambiguous early-stage RA. We measured this antibody in 100 patients who visited our outpatient clinic for a chief complaint of joint pains, and followed them up until 1 year later to study whether this antibody would be helpful in the prediction of RA development or in the diagnosis of RA. At the initial examination, 40% of those patients were positive for the antibody. After the one-year follow-up, 30 (75%) of the 40 antibody-positive cases were classified as having RA, while only 4 (7%) of the 60 antibody-negative cases were found to have RA (p<0.001). Specificity of the antibody testing was as high as 84.9%, indicating that the anti-CCP antibody measurement appears to be useful for prediction of RA development and helpful for RA diagnosis in patients with ‘arthralgia’.
Journal
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- Clinical Rheumatology and Related Research
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Clinical Rheumatology and Related Research 22 (1), 59-65, 2010
The Japanese Society for Clinical Rheumatology and Related Research
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Details 詳細情報について
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- CRID
- 1390001204340817664
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- NII Article ID
- 130005127425
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- ISSN
- 21890595
- 09148760
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed