造血細胞移植におけるナチュラルキラー細胞の役割

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  • Role of Natural Killer Cells on Hematopoietic Stem Cell Transplantation

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In recent years, with the rapid advance in the investigation of Natural Killer (NK) receptors and their ligands, it has become possible to explain unequivocally an immune phenomenon related to NK cells in hematopoietic cell transplantation. NK cells mainly possess a binary function of cellular cytotoxicity and cytokine production, and they play an important role in rejection, GVHD, and GVL in hematopoietic cell transplantation. Those immune phenomena may reduce complications and improve survival in hematopoietic cell transplantation when we understand and employ the action of a particularly inhibitory NK receptor. Thus, it is with a beneficial outcome of hematopoietic cell transplantation as functional weapon in mind that we evaluate the degree of concordance between NK receptor and HLA-C in terms of donor choice.

収録刊行物

  • 日本小児血液学会雑誌

    日本小児血液学会雑誌 21 (5/6), 208-216, 2007

    特定非営利活動法人　日本小児血液・がん学会

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