An infant case of autoimmune neutropenia.

DOI
  • TAKANO Masako
    Department of Pediatrics, Faculty of Medicine, Toyama Medical and Pharmaceutical University
  • YAMATANI Masami
    Department of Pediatrics, Faculty of Medicine, Toyama Medical and Pharmaceutical University
  • KUBOTA Hiromichi
    Department of Pediatrics, Faculty of Medicine, Toyama Medical and Pharmaceutical University
  • SUZAKI Ken
    Department of Pediatrics, Faculty of Medicine, Toyama Medical and Pharmaceutical University
  • KANEDA Miyuki
    Department of Blood Transfusion, Hiroshima University Hospital

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Other Title
  • 易感染性が著明であった自己免疫性好中球減少症の１乳児例　ＳＴ合剤の隔日投与による感染予防
  • ST合剤の隔日投与による感染予防

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A nontransfused 10-month-old female infant was admitted for recurrent infections and fever. On admission, absolute neutrophil counts ranged from 112 to 998/μl. Antibodies against neutrophils were examined with an indirect immunofluorescence test (GIIFT) and a microleukocyte agglutination test (MLAT). The patient's sera reacted with neutrophils from normal donors on GIIFT and MLAT. The results of a leukocyte cytotoxicity test were negative. These findings suggest that her neutropenia was caused by the autoantibody against neutrophils. Trimethoprim-sulfamethoxazole was given orally at a dose of 6 mg (trimethoprim) /kg/day every other day. Although the neutrophil counts did not increase after the treatment, the frequency of infections remarkably decreased. We conclude that oral administration of trimethoprim-sulfamethoxazole every other day was effective for the prophylaxis of infections of in our patient with autoimmune neutropenia.

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