書誌事項
- タイトル別名
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- IL-2 Production and Its Kinetics of Cord Blood Following Alloantigen Stimulation Implications in Cord Blood Stem Cell Transplantation.
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We previously reported that alloantigen-specific cytotoxic T lymphocytes (CTL) could be induced similarly in both cord and adult blood mononuclear cells. Here, we report the kinetics of IL-2 production of cord blood mononuclear cells and the effect of immunosuppressants on IL-2 production. A mixed lymphocyte culture was set up, using cord blood mononuclear cells as responders and irradiated allogeneic mononuclear cells of a healthy adult as stimulators. IL-2 concentration was serially determined from day 1 to day 6. There was no significant difference in IL-2 production in cord and adult blood mononuclear cells. Immunosuppressants, cyclosporin A and FK506, significantly inhibited IL-2 production. These in vitro results, together with our previous observation, suggest that IL-2-dependent CTL may cause graft-versus-host disease and also graft-versusleukemia effect in cord blood stem cell transplantation.
収録刊行物
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- 日本小児血液学会雑誌
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日本小児血液学会雑誌 11 (6), 414-419, 1997
特定非営利活動法人 日本小児血液・がん学会
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詳細情報 詳細情報について
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- CRID
- 1390001204342453120
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- NII論文ID
- 10012259823
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- NII書誌ID
- AN10080852
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- ISSN
- 18844723
- 09138706
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可