書誌事項
- タイトル別名
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- Study of L-Asparaginase-Induced Hyperlipidemia.
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An 8-year-old girl with ALL was treated by chemotherapy including L-asparaginase (L-ASP). In the course of the chemotherapy, transient hepatomegaly, fatty liver and type V hyperlipidemia of the Friedrickson classification developed. With the experience of this case, we prospectively measured lipid-related parameters during chemotherapies including L-ASP in 3 ALL cases. Decreased lipoprotein lipase (LPL) and hepatic triglyceride lipase (HTGL) activity and apoprotein C-II (apo C-II) were shown in all cases. In one of these cases, a patient eating a sufficient diet, chylomicron and very low-density lipoprotein (VLDL) increased after decreasing LPL and HTGL activity. Low LPL activity resulted from decreased LPL protein and apo C-II protein due to the inhibition of protein synthesis by L-ASP. We confirmed another hyperlipidemia pattern in an 8-year-old girl with ALL. Transient fatty liver and hyperlipidemia with a rapid peak were caused after chemotherapy, while at the same time, increased apoprotein was observed. The results suggest that decreasing LPL and HTGL activity with a protein-synthesis inhibitor by L-ASP causes exogenous hyperlipidemia, accumulation of lipids in the liver with hepatomegaly and transient fatty liver during chemotherapy. Endogenous hyperlipidemia after chemotherapy is caused by the removal of lipids from liver during recovery of the lipid metabolism.
収録刊行物
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- 日本小児血液学会雑誌
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日本小児血液学会雑誌 12 (2), 82-86, 1998
特定非営利活動法人 日本小児血液・がん学会
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詳細情報 詳細情報について
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- CRID
- 1390001204342877952
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- NII論文ID
- 10012258252
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- NII書誌ID
- AN10080852
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- ISSN
- 18844723
- 09138706
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可