マウスの酢酸ライジング反応に及ぼす柴胡加竜骨牡蛎湯慢性投与の効果

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  • Effects of Chronic Administration of Saiko-ka-ryukotsu-borei-to on Acetic Acid-Induced Writhing in Mice.

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Several kinds of traditional Chinese herbal (Kampo) medicines that contain Bupleuri Radix (Saiko) as one of the main ingredients have been reported to produce antinociceptive effects in mice after administration in drinking water for 14 consecutive days. Among these, Saiko-ka-ryukotsu-borei-to has been found to be the most potent. Kami-kihi-to, which has ingredients similar to those of Saiko-ka-ryukotsu-borei-to, has also been shown to produce antinociceptive effects after acute administration. We have therefore sought to determine the onset of antinociceptive effects induced by the chronic administration of Saiko-ka-ryukotsu-borei-to. Acetic acid-induced writhing in mice was observed on the 2 nd, 5 th, 8 th, 11th and 14th days after the start of administration. The amount of writhing observed was counted in consecutive 5 -min poriods for 60-min after the intraperitoneal injection of 0.6% acetic acid. The results showed that the highest dose of Saiko-ka-ryukotsu-borei-to (300mg/kg/day) produced its antinociceptive effects, assessed as a reduction in the amount of writhing, after 5 th day of administration. Slower onset (after the 8 th day) was seen with lower doses (60 and 150mg/kg/day), though the effects were not entirely dose-dependent. These results suggest that Saiko-ka-ryukotsu-borei-toneeds to be administered consecutively for at least one week to produce its antinociceptive effects.

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