A case of mucoepidermoid carcinoma of the oral floor treated successfully with preoperative daily concurrent chemoradiotherapy using superselective intra-arterial infusion via the superficial temporal artery

DOI 2 Citations 29 References
  • Baba Junichi
    Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine
  • Mitsudo Kenji
    Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine
  • Iwai Toshinori
    Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine
  • Fukui Takafumi
    Department of Oral and Maxillofacial Surgery, Chita City Hospital
  • Mitsunaga Sachiyo
    Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine
  • Watanuki Kei
    Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine
  • Hirota Makoto
    Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine
  • Matsui Yoshiro
    Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine
  • Tohnai Iwai
    Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine

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Other Title
  • 浅側頭動脈よりの超選択的動注法による術前連日同時放射線化学療法が著効した口底粘表皮癌の1例

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Abstract

We report a case of mucoepidermoid carcinoma of the oral floor treated successfully with daily concurrent chemoradiotherapy using superselective intra-arterial infusion via the superficial temporal artery (STA).<br>A 60s male was referred to our department with left mandibular pain and mental nerve palsy. The mass was 34 × 23 mm at the lingual side of left lower molars: A submandibular lymph node has no mobility. A CT scan showed a 42 × 24 mm mass at the lingual side of the mandible. The mass involved the mandible body. A biopsy was performed and the pathological diagnosis was mucoepidermoid carcinoma. The patient underwent superselective intra-arterial infusion via the STA combined with daily concurrent radiotherapy. The total dose of cisplatin was 224 mg, and that of docetaxel was 111 mg. External irradiation was performed five times a week at 1.8 Gy per fraction, for a total of 50.4 Gy. The clinical effect was partial response after the completion of treatments. The patient underwent segmental mandibulectomy, functional neck dissection and reconstruction with fibula osteocutaneous flap, four weeks after the end of intra-arterial chemoradiotherapy. The pathological diagnosis of the resected tumor and lymph nodes was complete response. The patient has been free of disease for 30 months since the operation.

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