Diagnosis and treatments of intrahepatic cholangiocarcinoma

DOI 1 Citations 30 References
  • Yamamoto Masakazu
    Department of Surgery, Institute of gastroenterology, Tokyo Women's Medical University
  • Ariizumi Shun-ichi
    Department of Surgery, Institute of gastroenterology, Tokyo Women's Medical University

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  • 肝内胆管癌の診断と治療

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Description

The incidence of intrahepatic cholangiocarcinoma (ICC) has been increasing in the world. Recently, hepatitis C virus infection and non-specific liver cirrhosis are recognized as causes of ICC. ICC is classified into three macroscopic types; mass-forming, periductal infiltrating and intraductal growth type. This classification is useful to determine the clinical status of patients and to predict surgical outcomes. Mass-forming type ICC is significantly related with hepatitis C virus infection and the clinicopathological findings of mass-forming type ICC are similar to those of hepatocellular carcinoma. Mass-forming plus periductal infiltrating type ICC is considered to be a more advanced tumor of periductal infiltrating ICC because of the clinical features and the histopathological findings. Multivariate analysis shows that lymph node metastasis, intrahepatic metastasis and curative resection are significant independent factors. Recurrence rates are high even if curative surgery is performed and therefore adjuvant therapy (immunotherapy and chemotherapy) should be performed for better survival.

Journal

  • Tando

    Tando 22 (2), 149-153, 2008

    Japan Biliary Association

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