Interstitial Hyperthermia Using Magnetite Cationic Liposomes Inhibit to Tumor Growth of VX-7 Transplanted Tumor in Rabbit Tongue.

DOI Web Site 9 Citations 14 References
  • MATSUNO HIDEYUKI
    Department of Maxillofacial Surgery, Nagoya University School of Medicine
  • TOHNAI IWAI
    Department of Maxillofacial Surgery, Nagoya University School of Medicine
  • MITSUDO KENJI
    Department of Maxillofacial Surgery, Nagoya University School of Medicine
  • HAYASHI YASUSHI
    Department of Maxillofacial Surgery, Nagoya University School of Medicine
  • ITO MASAFUMI
    Department of Pathology, Nagoya University Hospital
  • SHINKAI MASASHIGE
    Department of Biotechnology, Graduate School of Engineering, Nagoya University Hospital
  • KOBAYASHI TAKESHI
    Department of Biotechnology, Graduate School of Engineering, Nagoya University Hospital
  • YOSHIDA JUN
    Department of Neurosurgery, Nagaya University School of Medicine
  • UEDA MINORU
    Department of Maxillofacial Surgery, Nagoya University School of Medicine

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Other Title
  • Magnetite Cationic Liposome (MCLs) を用いた組織内加温療法は家兎VX-7移植舌腫瘍の増殖を抑制する
  • Interstitial hyperthermia using magnetite cationic liposomes to inhibit tumor growth of VX-7 transplanted tumor in rabbit tongue

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Abstract

We previously developed a new system of magnetic induction interstitial hyperthermia, implant heating system (IHS), and applied to oral cancer control. To overcome the limitations of this system, the present study dealt with new magnetic induction hyperthermia using Magnetic Cationic Liposomes (MCLs) which are injected into a tumor. We prepared a tongue tumor model using the transplantable rabbit VX-7 cells. MCL was injected into the tumor margins to heat the tumor selectively and induce blood vessel damage by heating. Two separated MCL injection sites were made by using Micro syringe pump and sandwiched the tumor on both sides.<BR>The rabbit in group I (n = 4) were performed hyperthermia, while those in group II (n= 4) were not subjected to magnetic field irradiation as the control. In the experimental rabbits, the temperature in the tumor was as high as 43.0°C. The tumor volumes of irradiated rabbits were significantly smaller than those of the non irradiated ones. The transplanted tumor of experimental rabbits almost completely disappeared following 18 day after treatment. The tongues, removed from irradiated rabbits on 28th day after irradiation, showed no tumor cells and fibrous tissue replacement completely occurred in the implanted tumor area. Tongue muscle adjacent to the MCL injection sites did not exhibit any evidence of inflammation or necrosis. The present study confirmed the effectiveness of interstitial hyperthermia using MCLs against oral carcinoma.

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