Interleukin-6 affects cancer cell biology

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  • Nishino Hiroshi
    Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Jichi Medical University

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  • IL-6と癌細胞活性

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Interleukin-6 (IL-6) is representative typical inflammatory cytokines. IL-6 is now recognized as important mediators linking inflamation and cancer cell biology. Il-6 affects cell proliferation, resistance for apoptosis, invasion, angiogenesis, metastasis, immunity, stem cell, and cachexia. IL-6 is highly up-regulated in many cancers and considered as one of the most important cytokine families during tumorigenesis and metastasis. This review discusses a mechanisms of IL-6 cytokine to tumorigenesis and metastasis.



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