Helper T-cell based immunotherapy combined with adjuvants in head and neck squamous cell carcinoma

DOI IR 39 References Open Access
  • Kumai Takumi
    Department of Otolaryngology-Head and Neck Surgery, Asahikawa Medical University
  • Nagato Toshihiro
    Department of Otolaryngology-Head and Neck Surgery, Asahikawa Medical University
  • Takahara Miki
    Department of Otolaryngology-Head and Neck Surgery, Asahikawa Medical University
  • Kobayashi Hiroya
    Department of Pathology, Asahikawa Medical University
  • Harabuchi Yasuaki
    Department of Otolaryngology-Head and Neck Surgery, Asahikawa Medical University

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Other Title
  • ヘルパーT 細胞と免疫アジュバントを用いた頭頸部癌免疫治療の開発

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Overexpression of tumor antigens is commonly observed in head and neck squamous cell carcinoma (HNSCC) that is a fatal and common disease in Japan. Although some tumor antigen molecules on HNSCC have been elucidated, effective immunotherapy using these antigens for HNSCC has not been developed. We previously showed that tumor antigen-specific helper T cells had the ability to kill HNSCC cell lines. Moreover, immune modulators such as EGFR inhibitors could upregulate these antitumor T cell responses. In this review, we present the current understanding of helper T-cell mediated anti-tumor immunity and molecule-targeted therapies that can augment anti-tumor T-cell responses. A detailed understanding of anti-tumor immunity and the mechanisms of immune enhancers may provide a platform for establishing combinatorial immunotherapy with adjuvants in treatment for HNSCC.

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