Anti-obesity effect of joint oral administration of a tannase producing <i>Lactobacillus plantarum</i> and epigallocatechingallate in mice

DOI 26 References
  • HAYASHI Taeko
    Research and Development Div, Maruzen Pharmaceuticals Co. Ltd.
  • UEDA Shuhei
    Animal Science Division, Department of Bioresource Science, Graduate School of Agricultural Science, Kobe University
  • NOMOTO Ryohei
    Organization of Advanced Science and Technology Kobe University
  • KUWAHARA Hiroshige
    Research and Development Div, Maruzen Pharmaceuticals Co. Ltd.
  • OSAWA Ro
    Animal Science Division, Department of Bioresource Science, Graduate School of Agricultural Science, Kobe University

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  • タンナーゼ産生<i>Lactobacillus plantarum</i>とエピガロカテキン没食子酸エステルの経口併投与によるマウスにおける抗肥満作用の検証

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Abstract

Green tea catechins are known to have various beneficial effects for the maintenance and promotion of human health, and their anti-obesity effects have recently been highlighted. However, galloylesters of the green tea catechins, such as epigallocathechingallate (EGCg) and epicathechingallate, are known to bind quickly with food ingredients (i.e. proteins) to form a complex that is likely to be inabsorbable through the host intestine, whereas non-esterified catechins such as epi-gallocathechin (EGC) and epicathechin are not. We recently demonstrated that tannase producing Lactobacillus plantarum 22A-3 hydrolyzed EGCg complexed with food ingredients to yield EGC and gallic acid in vitro. In this context, we determined whether an oral administration of L. plantarum 22A-3 hydrolyzed the complex to EGC, thereby exerting an anti-obesity effect in mice. Our results show that joint oral administration of L. plantarum 22A-3 and EGCg markedly reduced not only EGCg content in feces but also total visceral fat per body weight of the mice. The evidence suggests that L. plantarum 22A-3 hydrolyze EGCg complexed with food ingredients to EGC in vivo. This in turn presents the prospect of a probiotic use for L. plantarum 22A-3 to enhance the anti-obesity effect of green tea cathechins.<br>

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