Titration of bases and their salts with perchloric acid in acetic anhydride and glacial acetic acid.

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Other Title
  • 無水酢酸‐氷酢酸溶液中における塩基及びその塩の過塩素酸滴定
  • ムスイ サクサン ヒョウサクサン ヨウエキチュウ ニ オケル エンキ オヨビ
  • 無水酢酸-氷酢酸溶液中における塩基及びその塩の過塩素酸滴定
  • 局方薬品の非水滴定(第2報)

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Abstract

Weak bases and their salts listed in Japanese Pharmacopoeia were determined by nonaqueous titration after extraction or hydrolysis. Aim of this study was to omit the troublesome pretreatments. The drugs were determined directly by potentiometric titration with perchloric acid in acetic anhydride-glacial acetic acid (10:07:3). The titration curves, the first and second derivative curves after smoothing, were recorded on an automatic titrator assisted by a microcomputer. Sodium benzoate (Ib) and caffeine (Ia) of their mixture (I) were determined by two steps of titration curves, respectively. Imipramine hydrochloride (II) and hydroxyzine pamoate (IV) were determined by the first and second steps, respectively. Diphenhydramine tannate (III) gave a clear end point. Phenacetin (V) showed a small potential jump at the end point only on the derivative curve. Standard deviation of this method was ca. 0.3% for IIV and 0.8% for V. It was estimated from the potential of glass electrode at the half equivalent point that the order of base strength was alkylamines (II, III, IV), sodium carboxylate (Ib), amine hydrochlorides (II, IIIa), diarylmethylamine (IV), purine (Ia), amide (V) and diarylamine (II).

Journal

  • BUNSEKI KAGAKU

    BUNSEKI KAGAKU 37 (7), 339-343, 1988

    The Japan Society for Analytical Chemistry

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