Study on thin-layer chromatography of ciclopirox olamine

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Other Title
  • シクロピロックスオラミンの薄層クロマトグラフィー
  • シクロピロックスオラミン ノ ハクソウ クロマトグラフィー ノート

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Description

A yellow spot besides ciclopirox olamine spot was observed when ciclopirox olamine was subjected to the thin-layer chromatography. Ciclopirox olamine (Rf 0.40) and a yellow spot (Rf 0.65) were observed in UV light or daylight, when ciclopirox olamine was developed on a silica gel F254 plate by using benzene-ethanol (93:7) as a developer. A yellow spot was produced by the reaction of ciclopirox olamine with Fe, about 0.02% of which was contained in silica gel, under the development. The yellow spot was identified as the ciclopirox-Fe chelate (C36H48FeN3O6) after comparative studies between ciclopirox-Fe chelate and the yellow spot by UV, IR and atomic absorption spectrochemical analysis of Fe. On a thin-layer chromatographic plate with a refined silica gel (ca. 0.002% of Fe was contained) or silica gel on sale (ca. 0.02% of Fe was contained) treated with hydrochloric acid and with addition of fluorescent agent ciclopirox olamine (Rf 0.40) was only observed.

Journal

  • BUNSEKI KAGAKU

    BUNSEKI KAGAKU 25 (6), 406-408, 1976

    The Japan Society for Analytical Chemistry

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