Determination of Perfluorinated Compounds in Human Milk and Evaluation of Their Transition from Maternal Plasma

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  • Nakata Ayako
    Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences Hoshi University
  • Saito Koichi
    Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences Hoshi University
  • Iwasaki Yusuke
    Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences Hoshi University
  • Ito Rie
    Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences Hoshi University
  • Kishi Reiko
    Department of Public Health, Hokkaido University Graduate School of Medicine
  • Nakazawa Hiroyuki
    Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences Hoshi University

Bibliographic Information

Other Title
  • 乳汁中ペルフルオロ化合物の定量及び母体血からの移行性
  • ニュウジュウ チュウ ペルフルオロ カゴウブツ ノ テイリョウ オヨビ ボタイ ケツ カラ ノ イコウセイ
  • Determination of perfluorinated compounds in human milk and evaluation of their transition from maternal plasma [in Japanese]

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Description

In this study, we focused our attention on breast fluid as specific perfluorinated compounds (PFCs) as an exposure source to infants, and developed a highly sensitive and accurate analytical method using high-performance liquid chromatography/tandem mass spectrometry (LC/MS/MS). For sample pretreatment, samples were determined using weak anion exchange (WAX) and solid phase extraction (SPE). The average recoveries of the analytes were in the range 94.3∼109.0% (RSD <10.3%), and the limits of quantitation (LOQ) were determined to be 0.012 ng/mL for PFOA and 0.004 ng/mL for PFOS, PFHxS and PFNA, respectively. Relatively high levels of PFCs were detected from human milk, which ranged over 0.046∼0.098 ng/mL for PFOS and over 0.016∼0.270 ng/mL for PFOA. In addition, human milk and maternal plasma collected from the same donor were analyzed. As a result, the concentration of PFCs in human milk and maternal plasma showed significant correlations for PFOS (r = 0.78) and PFOA (r = 0.82).

Journal

  • BUNSEKI KAGAKU

    BUNSEKI KAGAKU 58 (8), 653-659, 2009

    The Japan Society for Analytical Chemistry

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